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PF-2771 

Cat. No. M29159

All AbMole products are for research use only, cannot be used for human consumption.

PF-2771  Structure

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Quality Control & Documentation
Biological Activity

PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent.

Chemical Information
Molecular Weight 554.08
Formula C29H36ClN5O4
CAS Number 2070009-55-9
Form Solid
Solubility (25°C) DMSO ≥ 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jung-Hyun Kim, et al. Oncotarget. Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

[2] Pei-Pei Kung, et al. Mol Cancer Ther. Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer

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  Catalog
Abmole Inhibitor Catalog




Keywords: PF-2771  supplier, Kinesin, inhibitors, activators

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