Free shipping on all orders over $ 500

Pentamidine dihydrochloride

Cat. No. M2922
Pentamidine dihydrochloride Structure
Synonym:

MP601205 dihydrochloride

Size Price Availability
1g USD 380  USD380 Custom Synthesis
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.

Chemical Information
Molecular Weight 413.34
Formula C19H24N4O2.2HCl
CAS Number 50357-45-4
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] R M Sieve, et al. Pentamidine

[2] M Sands, et al. Pentamidine: a review

[3] B Gazzard. Pentamidine

[4] B Wispelwey, et al. Pentamidine. A risk-benefit analysis

[5] B Wispelwey, et al. Pentamidine: a review

Related Parasite Products
Argifin

Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms.

Argadin

Argadin is a cyclopentapeptide chitinase inhibitor.

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS is a fluorescent dye, and can be applied in a fluorogenic substrate for an aspartyl proteinase from human malaria parasite.

Xenopsin precursor fragment

Xenopsin precursor fragment is an antimicrobial peptide, and has antibacterial/antifungal (10-500 μg/mL) and anti-protozoal (MIC: 2-20 μg/mL) activity.

Dihydrocyclosporin A

Dihydrocyclosporin A is a derivative of Cyclosporine A.

  Catalog
Abmole Inhibitor Catalog




Keywords: Pentamidine dihydrochloride, MP601205 dihydrochloride supplier, Parasite, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.