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PD 102807 

Cat. No. M29495

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PD 102807  Structure

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Quality Control & Documentation
Biological Activity

PD 102807 is a M4 muscarinic receptor antagonist with an IC50 of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC50s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively. Antidyskinetic effect.

Chemical Information
Molecular Weight 392.45
Formula C23H24N2O4
CAS Number 23062-91-1
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ikunobu Muramatsu, et al. J Neurochem. Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer's disease drugs

[2] Michael Marks, et al. Br Med Bull. Yaws

[3] Michael Marks, et al. Int J STD AIDS. Yaws

[4] Eric Tompkins, et al. Am J Respir Cell Mol Biol. PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells

[5] M C Olianas, et al. Life Sci. PD 102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP

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Keywords: PD 102807  supplier, AChR/AChE, inhibitors, activators

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