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Fezagepras sodium

Cat. No. M28051

All AbMole products are for research use only, cannot be used for human consumption.

Fezagepras sodium Structure
Synonym:

Setogepram sodium; PBI-4050 sodium

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Quality Control & Documentation
Biological Activity

Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras sodium decreases renal, liver and pancreatic fibrosis. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.

Chemical Information
Molecular Weight 228.26
Formula C13H17NaO2
CAS Number 1254472-97-3
Form Solid
Solubility (25°C) Water ≥ 100 mg/mL
DMSO ≥ 64 mg/mL
Storage 4°C, dry, sealed
References

[1] Lin-Hai Chen, et al. J Med Chem. Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists

[2] Frédéric Labéguère, et al. J Med Chem. Discovery of 9-Cyclopropylethynyl-2-(( S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1- a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

[3] Jean-François Thibodeau, et al. Clin Sci (Lond). PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice

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  Catalog
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Keywords: Fezagepras sodium, Setogepram sodium; PBI-4050 sodium supplier, GPR/FFAR, inhibitors, activators

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