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Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab , potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors.
Immobilized human HER3 His at 2 ug/mL can bind patritumab, EC50=0.04264 ug/mL.
Human HER3 HEK293 cells were stained with patritumab and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.2297 ug/mL.
| Molecular Weight | 146860 |
| CAS Number | 1262787-83-6 |
| Storage | Store at ≤ -20℃ for 24 months. Avoid repeated freeze-thaw cycles. |
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