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PAT-505

Cat. No. M11452
PAT-505  Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pat-505 is a potent, selective, non-competitive, oral autotaxin inhibitor that inhibits autotaxin activity in Hep3B with an IC50 value of 2 nM, 9.7 nM in human blood and 62 nM in mouse plasma, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 473.92
Formula C23H18ClF2N3O2S
CAS Number 1782070-22-7
Purity >98%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: PAT-505 supplier, inhibitors

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