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Paroxetine HCl is an antidepressant compound of the SSRI type. Paroxetine (10 μM) reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells. Paroxetine (0-5 μM) leads to a dose-dependent inhibition on LPS-induced production of TNF-α and IL-1β in BV2 cells. Paroxetine also inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BV2 cells. Paroxetine (5 μM) blocks LPS-induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells.
| Molecular Weight | 365.83 |
| Formula | C19H20FNO3.HCl |
| CAS Number | 78246-49-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL Water 6 mg/mL |
| Storage | 4°C, dry, sealed |
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