Free shipping on all orders over $ 500

Parbendazole

Cat. No. M20683
Parbendazole Structure
Synonym:

SKF 29044

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Parbendazole is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.

Chemical Information
Molecular Weight 247.29
Formula C13H17N3O2
CAS Number 14255-87-9
Solubility (25°C) DMSO 3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dong Liang, et al. Acta Pharm Sin B. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

[2] Jia-Hong Lei, et al. RSC Adv. Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

[3] Rosalba Florio, et al. Cancers (Basel). The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer

[4] Andrea M Brum, et al. Proc Natl Acad Sci U S A. Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

[5] Badraddin M H Al-Hadiya. Profiles Drug Subst Excip Relat Methodol. Parbendazole

Related Microtubule Products
P34cdc2 Kinase Fragment

P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis.

Cemadotin

Cemadotin (LU103793) is an analogue of Dolastatin 15 which is naturally occurring cytotoxic peptides.

VLS-1488

VLS-1488 is an orally active KIF18A inhibitor that inhibits KIF18A microtubule-dependent ATPase activity with an IC50 value of 0.016 μM.

ENMD-1198

ENMD-1198 (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity.

Tubulin/JAK2-IN-1

Tubulin/JAK2-IN-1 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule.

  Catalog
Abmole Inhibitor Catalog




Keywords: Parbendazole, SKF 29044 supplier, Microtubule, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.