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Cat. No. M20683
Parbendazole Structure

SKF 29044

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Biological Activity

Parbendazole is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules.

Chemical Information
Molecular Weight 247.29
Formula C13H17N3O2
CAS Number 14255-87-9
Solubility (25°C) DMSO 3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dong Liang, et al. Acta Pharm Sin B. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning

[2] Jia-Hong Lei, et al. RSC Adv. Structural insights into targeting of the colchicine binding site by ELR510444 and parbendazole to achieve rational drug design

[3] Rosalba Florio, et al. Cancers (Basel). The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer

[4] Andrea M Brum, et al. Proc Natl Acad Sci U S A. Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

[5] Badraddin M H Al-Hadiya. Profiles Drug Subst Excip Relat Methodol. Parbendazole

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Abmole Inhibitor Catalog

Keywords: Parbendazole, SKF 29044 supplier, Microtubule, inhibitors, activators

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