Free shipping on all orders over $ 500

PAR-2 (6-1) amide (human)

Cat. No. M10238
PAR-2 (6-1) amide (human) Structure
Synonym:

VKGILS-NH2

Size Price Availability
5mg USD 150  USD150 4-7 Days
25mg USD 550  USD550 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

VKGILS-NH2 is a reversed amino acid sequence control peptide for SLIGKV-NH2.

Chemical Information
Molecular Weight 614.78
Formula C28H54N8O7
CAS Number 942413-05-0
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] David A Vesey, et al. Am J Physiol Renal Physiol. Proinflammatory and proliferative responses of human proximal tubule cells to PAR-2 activation

[2] M Tognetto, et al. Br J Pharmacol. Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder

Related PAR Products
TRAP-6 amide

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.

Protease-Activated Receptor-1, PAR-1 Agonist

Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide.

FSLLRY-NH2

FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor.

iso-TRAP-6

iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets.

PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

  Catalog
Abmole Inhibitor Catalog




Keywords: PAR-2 (6-1) amide (human), VKGILS-NH2 supplier, PAR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.