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P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer (10 μM; 0, 1, 3, 6, 24 h) stabilizes Nrf2 and (10 μM; 9 h) upregulates P62 expression activating mitophagy. P62-mediated mitophagy inducer positively affects mitochondrial poly-ubiquitination and coupling.
| Molecular Weight | 392.15 |
| Formula | C14H9IN4O2 |
| CAS Number | 1809031-84-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 4 mg/mL |
| Storage | Powder -20°C |
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