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Oxibendazole

Cat. No. M5841
Oxibendazole  Structure
Size Price Availability Quantity
50mg USD 90  USD90 In stock
100mg USD 160  USD160 In stock
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Quality Control & Documentation
Biological Activity

Obendazole is a class of benzimidazole compounds that interfere with metabolic pathways and are used to protect horses and some domestic pets from infections with roundworms, strongyworms, pinworms and lungworms.

Chemical Information
Molecular Weight 249.27
Formula C12H15N3O3
CAS Number 20559-55-1
Form Solid
Solubility (25°C) 1 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gottschall DW, et al. Vet Parasitol. Depletion and bioavailability of 14C-oxibendazole residues in swine tissues.

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