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Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.
| Molecular Weight | 400.55 |
| Formula | C25H36O4 |
| CAS Number | 4611-05-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Maurizio Vurro, et al. Augmented phytotoxic effect of nanoencapsulated ophiobolin A
[3] Danny Q Thach, et al. Total Synthesis of (+)-6-epi-Ophiobolin A
[5] Marco Masi, et al. Chemistry and biology of ophiobolin A and its congeners
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