ONO-8430506 is a potent autotaxin phosphodiesterase inhibitor with significant oral exposure and low clearance in higher species.
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Baasanjav Uranbileg, et al. Sci Rep. Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis
 Yuzo Iwaki, et al. ACS Med Chem Lett. ONO-8430506: A Novel Autotaxin Inhibitor That Enhances the Antitumor Effect of Paclitaxel in a Breast Cancer Model
 Matthew G K Benesch, et al. Endocr Relat Cancer. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer
 Matthew G K Benesch, et al. J Lipid Res. Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate
 Matthew G K Benesch, et al. FASEB J. Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice
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