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Oleandrigenin

Cat. No. M18886
Oleandrigenin Structure
Synonym:

Oleandrisenin

Size Price Availability Quantity
5mg USD 1350  USD1350 In stock
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Quality Control & Documentation
Biological Activity

Oleandrigenin is a metabolite and an Na(+)/K(+)-transporting ATPase inhibitor. Oleandrigenin is a steroid ester that is the 16-acetyl derivative of gitoxigenin.

Chemical Information
Molecular Weight 432.55
Formula C25H36O6
CAS Number 465-15-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zachary Fejedelem, et al. J Org Chem. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B

[2] Anna Carfora, et al. Forensic Sci Med Pathol. Fatal poisoning by ingestion of a self-prepared oleander leaf infusion

[3] Karol Michalak, et al. Eur J Med Chem. Synthesis and evaluation of Na +/K +-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues

[4] Karol Michalak, et al. Eur J Med Chem. Synthesis and evaluation of cytotoxic and Na +/K +-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives

[5] S A Jortani, et al. Clin Chem. Inhibition of Na,K-ATPase by oleandrin and oleandrigenin, and their detection by digoxin immunoassays

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