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NX-13

Cat. No. M45116

All AbMole products are for research use only, cannot be used for human consumption.

NX-13 Structure
Synonym:

Amelenodor

Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 280  USD280 In stock
10mg USD 440  USD440 In stock
25mg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

NX-13 is a novel oral small molecule NLRX1 agonist, which can increase oxidative phosphorylation in immune cells, decrease the differentiation of effector CD4+ T cells, and reduce the production of inflammatory cytokines in the gastrointestinal tract through activation of the NLRX1 pathway, and can be used in studies related to ulcerative colitis (UC).

Chemical Information
Molecular Weight 399.44
Formula C24H21N3O3
CAS Number 2389235-01-0
Solubility (25°C) DMSO >100 mg/mL
Storage -20°C
References

[1] Yu Song, et al. Autophagy. The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking

[2] Li Chen, et al. Acta Pharmacol Sin. NOD-like receptors in autoimmune diseases

[3] Andrew Leber, et al. J Immunol. Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells

[4] Andrew Leber, et al. Drug Chem Toxicol. Exploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1

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  Catalog
Abmole Inhibitor Catalog




Keywords: NX-13, Amelenodor supplier, NLR, inhibitors, activators

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