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NVP-BSK805

Cat. No. M11186
NVP-BSK805 Structure
Synonym:

BSK805

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NVP-BSK805 is a potent, selective, ATP competitive JAK2 inhibitor with an IC50 of 0.5 nM, which is more than 20 times more selective than acting on JAK1, JAK3 and TYK2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 490.55
Formula C27H28F2N6O
CAS Number 1092499-93-8
Purity >99%
Solubility N/A
Storage 4°C, dry, sealed
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GDC046

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  Catalog
Abmole Inhibitor Catalog




Keywords: NVP-BSK805, BSK805 supplier, JAK, inhibitors

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