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2-Aminoisobutyric acid

Cat. No. M19961
2-Aminoisobutyric acid Structure
Synonym:

NSC-16590; 2-Methylalanine; H-Aib-OH

Size Price Availability Quantity
100mg USD 46  USD46 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 103.12
Formula C4H9NO2
CAS Number 62-57-7
Purity >99%
Solubility Water 10.29 mg/mL
Storage at -20°C
References

[1] Takashi Misawa, et al. Chem Commun (Camb). Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

[2] Michal Douša. J Pharm Biomed Anal. Quantification of 2-aminoisobutyric acid impurity in enzalutamide bulk drug substance using hydrophilic interaction chromatography with fluorescence detection

[3] Kousuke Tsuchiya, et al. Chem Commun (Camb). Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

[4] S Ogilvie-Villa, et al. J Bacteriol. Characterization of 2-aminoisobutyric acid transport in Neurospora crassa: a general amino acid permease-specific substrate

[5] J R Bergesse, et al. Toxicol Lett. Changes in 2-aminoisobutyric acid and cycloleucine uptake produced by 2,4-dichlorophenoxyacetic acid in Chinese hamster ovary cells

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Keywords: 2-Aminoisobutyric acid, NSC-16590; 2-Methylalanine; H-Aib-OH supplier, inhibitors

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