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2-Aminoisobutyric acid

Cat. No. M19961
2-Aminoisobutyric acid Structure
Synonym:

NSC-16590; 2-Methylalanine; H-Aib-OH

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100mg USD 46  USD46 In stock
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Biological Activity

2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin.

Chemical Information
Molecular Weight 103.12
Formula C4H9NO2
CAS Number 62-57-7
Form Solid
Solubility (25°C) Water 10.29 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Takashi Misawa, et al. Chem Commun (Camb). Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

[2] Michal Douša. J Pharm Biomed Anal. Quantification of 2-aminoisobutyric acid impurity in enzalutamide bulk drug substance using hydrophilic interaction chromatography with fluorescence detection

[3] Kousuke Tsuchiya, et al. Chem Commun (Camb). Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

[4] S Ogilvie-Villa, et al. J Bacteriol. Characterization of 2-aminoisobutyric acid transport in Neurospora crassa: a general amino acid permease-specific substrate

[5] J R Bergesse, et al. Toxicol Lett. Changes in 2-aminoisobutyric acid and cycloleucine uptake produced by 2,4-dichlorophenoxyacetic acid in Chinese hamster ovary cells

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Keywords: 2-Aminoisobutyric acid, NSC-16590; 2-Methylalanine; H-Aib-OH supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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