About 9 results found for searched term "62-57-7" (0.057 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4191 | Polygalaxanthone-III | Cytochrome P450 (e.g. CYP17) |
| Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM. | ||
| M8853 | WIN 62,577 | Others |
| Non-peptide NK1 tachykinin receptor antagonist. | ||
| M18488 | Polygalasaponin II | Others |
| Polygalasaponin II | ||
| M19961 | 2-Aminoisobutyric acid | Metabolite/Endogenous Metabolite |
| NSC-16590; 2-Methylalanine; H-Aib-OH | ||
| 2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. | ||
| M28091 | NB-360 | Gamma-secretase/Beta-secretase |
| NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E. | ||
| M28910 | BAY-7598 | MMP |
| BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively. | ||
| M29067 | Farglitazar | PPAR |
| GI262570; GI262570X | ||
| Farglitazar is a PPARγ agonist that has significant therapeutic benefits such as glycemic control in type 2 diabetic patients. | ||
| M29538 | CRBN-6-5-5-VHL | PROTAC |
| CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3. | ||
| M45387 | VBIT-4 | VDAC |
| VBIT-4 is a voltage-dependent anion channel (VDAC1) oligomer inhibitor with a Kd value of 17 μM.In addition, VBIT-4 is an inhibitor of apoptosis and can be used in studies related to neurodegenerative and cardiovascular diseases. | ||
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