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NS3861 

Cat. No. M29318

All AbMole products are for research use only, cannot be used for human consumption.

NS3861  Structure

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Quality Control & Documentation
Biological Activity

NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding Ki values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively.

Chemical Information
Molecular Weight 284.22
Formula C12H14BrNS
CAS Number 216853-59-7
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
References

[1] Aravind R Gade, et al. J Pharmacol Exp Ther. Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation

[2] Kasper Harpsøe, et al. J Biol Chem. Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

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  Catalog
Abmole Inhibitor Catalog




Keywords: NS3861  supplier, AChR/AChE, inhibitors, activators

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