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Notoginsenoside Fc is a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy. Notoginsenoside Fc (20 μM; for 24 h) markedly upregulates the expression of LC3B and Beclin 1 and downregulated that of p62 in RAOECs.
In vivo, Notoginsenoside Fc (3.5 mg/kg/day) accelerates reendothelialization and alleviates excessive neointimal formation following carotid artery injury in diabetic Sprague-Dawley rats (200±20 g).
| Molecular Weight | 1211.38 |
| Formula | C58H98O26 |
| CAS Number | 88122-52-5 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
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