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NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure.
| Molecular Weight | 207.23 |
| Formula | C10H13N3O2 |
| CAS Number | 64091-91-4 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 62.5 mg/mL |
| Storage | Powder -20°C |
[2] Marissa E Di, et al. Methods Cell Biol. Lung carcinomas induced by NNK and LPS
| Related Metabolite/Endogenous Metabolite Products |
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| Casein (from bovine milk)
Casein is a phosphorus-containing complex protein with α-casein and β-casein as its main components. Casein is an orally active phosphoprotein that can be separated into various electrophoretic components, such as α2-Casein, κ-Casein, β-casein, and γ-casein. Casein can be used in biochemical research, to formulate biological culture media, and as a thickener, emulsifier and stabiliser. |
| Palmitic acid-13C16
Palmitic acid-13C16 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. |
| Methionine sulfoximine
Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine. |
| L-Glutamine-15N2
L-Glutamine-15N2 is the 15N-labeled L-Glutamine. L-Glutamine is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. |
| S-Me-DM4
S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. |
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