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NLG802

Cat. No. M21276
NLG802  Structure
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Biological Activity

NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

Chemical Information
Molecular Weight 395.92
Formula C20H30ClN3O3
CAS Number 2071683-99-1
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sanjeev Kumar, et al. Eur J Med Chem. Discovery of indoximod prodrugs and characterization of clinical candidate NLG802

Related IDO Products
IDO-IN-18

IDO-IN-18 is an IDO inhibitor.

IDO1-IN-21

IDO1-IN-21 is an IDO1 inhibitor (IC50 = 0.64 μM).

IDO1-IN-22

IDO1-IN-22 is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM).

IDO1/TDO-IN-6

IDO1/TDO-IN-6 is a dual inhibitor of IDO1/TDO with IC50s of 2.25 and 2.89 μM, respectively.

IDO-IN-13 

IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43.

  Catalog
Abmole Inhibitor Catalog




Keywords: NLG802 supplier, IDO, inhibitors, activators


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