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NLG802

Cat. No. M21276

All AbMole products are for research use only, cannot be used for human consumption.

NLG802  Structure

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Quality Control & Documentation
Biological Activity

NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

Chemical Information
Molecular Weight 395.92
Formula C20H30ClN3O3
CAS Number 2071683-99-1
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Sanjeev Kumar, et al. Eur J Med Chem. Discovery of indoximod prodrugs and characterization of clinical candidate NLG802

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(S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

IDO2-IN-1

IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for the research of inflammatory autoimmunity.

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IDO-IN-18

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  Catalog
Abmole Inhibitor Catalog




Keywords: NLG802 supplier, IDO, inhibitors, activators

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