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Nerol

Cat. No. M19460
Nerol Structure
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Biological Activity

Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity.

Chemical Information
Molecular Weight 154.25
Formula C10H18O
CAS Number 106-25-2
Form Liquid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Muhammad Torequl Islam, et al. Biomed Pharmacother. Effects of nerol on paracetamol-induced liver damage in Wistar albino rats

[2] Brian Ogushi Silva, et al. J Toxicol Environ Health A. Genotoxicity induced by nerol, an essential oil present in citric plants using human peripheral blood mononuclear cells (PBMC) and HepG2/C3A cells as a model

[3] Xueyan Mo, et al. Microb Cell Fact. Whole genome sequencing and metabolomics analyses reveal the biosynthesis of nerol in a multi-stress-tolerant Meyerozyma guilliermondii GXDK6

[4] Zhen Zong, et al. Bioresour Technol. Biosynthesis of nerol from glucose in the metabolic engineered Escherichia coli

[5] A Lapczynski, et al. Food Chem Toxicol. Fragrance material review on nerol

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Keywords: Nerol supplier, ROS, inhibitors, activators


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