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Cat. No. M9519
Nelonicline Structure


Size Price Availability
5mg USD 180  USD200 4-7 Days
10mg USD 270  USD300 4-7 Days
50mg USD 810  USD900 4-7 Days
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

Nelonicline at 0.10 mg/kg reduces LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. ABT-126 reduces dyskinesias in both early- and later-stage Parkinson's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 313.42
Formula C17H19N3OS
CAS Number 1026134-63-3
Purity >97%
Solubility DMSO
Storage at -20°C

Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR)
Thomas J Hudzik, et al. Pharmacol Biochem Behav. 2017 Jul;158:22-31. PMID: 28579351.

Partial agonism at the α7 nicotinic acetylcholine receptor improves attention, impulsive action and vigilance in low attentive rats
Andrew Hayward, et al. Eur Neuropsychopharmacol. 2017 Apr;27(4):325-335. PMID: 28161246.

α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage.
Zhang D, et al. Mov Disord. 2015 Dec;30(14):1901-1911. PMID: 26573698.

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker.
Hashimoto K, et al. Curr Pharm Des. 2015;21(26):3797-806. PMID: 26044974.

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Keywords: Nelonicline, ABT-126 supplier, AChR/AChE, inhibitors

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