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Nelonicline

Cat. No. M9519
Nelonicline Structure
Synonym:

ABT-126

Size Price Availability
5mg USD 200  USD200 4-7 Days
10mg USD 300  USD300 4-7 Days
50mg USD 900  USD900 4-7 Days
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Quality Control & Documentation
Biological Activity

Nelonicline at 0.10 mg/kg reduces LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. ABT-126 reduces dyskinesias in both early- and later-stage Parkinson's disease.

Chemical Information
Molecular Weight 313.42
Formula C17H19N3OS
CAS Number 1026134-63-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Thomas J Hudzik, et al. Pharmacol Biochem Behav. Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR)

[2] Andrew Hayward, et al. Eur Neuropsychopharmacol. Partial agonism at the α7 nicotinic acetylcholine receptor improves attention, impulsive action and vigilance in low attentive rats

[3] Zhang D, et al. Mov Disord. α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage.

[4] Hashimoto K, et al. Curr Pharm Des. Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker.

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