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NCGC00244536

Cat. No. M13837
NCGC00244536 Structure
Synonym:

KDM4B Inhibitor B3

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 382.45
Formula
CAS Number 2003260-55-5
Purity >99%
Solubility DMSO 36.67 mg/mL
Storage at -20°C
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Keywords: NCGC00244536, KDM4B Inhibitor B3 supplier, Histone demethylases, inhibitors

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