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NAPQI is the toxic metabolite of Acetaminophen. NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.
| Molecular Weight | 149.15 |
| Formula | C8H7NO2 |
| CAS Number | 50700-49-7 |
| Form | Solid |
| Storage | -80°C, protect from light, sealed |
[4] Erik S Fisher, et al. Adv Pharmacol. Evaluation and treatment of acetaminophen toxicity
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