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NAPQI 

Cat. No. M30204

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NAPQI  Structure

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Quality Control & Documentation
Biological Activity

NAPQI is the toxic metabolite of Acetaminophen. NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.

Chemical Information
Molecular Weight 149.15
Formula C8H7NO2
CAS Number 50700-49-7
Form Solid
Storage -80°C, protect from light, sealed
References

[1] Yuan-Kai Sun, et al. Pharmacol Res. Progress in the treatment of drug-induced liver injury with natural products

[2] Xiaopeng Cai, et al. J Zhejiang Univ Sci B. Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

[3] Hartmut Jaeschke, et al. Acta Pharm Sin B. Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

[4] Erik S Fisher, et al. Adv Pharmacol. Evaluation and treatment of acetaminophen toxicity

[5] K Brune, et al. Eur J Pain. Acetaminophen/paracetamol: A history of errors, failures and false decisions

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  Catalog
Abmole Inhibitor Catalog




Keywords: NAPQI  supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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