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N-Butyl-N-(4-hydroxybutyl)nitrosamine

Cat. No. M45118
N-Butyl-N-(4-hydroxybutyl)nitrosamine Structure
Synonym:

BBN

Size Price Availability Quantity
250mg USD 70  USD70 In stock
1g USD 110  USD110 In stock
5g USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

N-Butyl-N-(4-hydroxybutyl)nitrosamine can be used to construct animal models of bladder cancer (BLCA).

Chemical Information
Molecular Weight 174.24
Formula C8H18N2O2
CAS Number 3817-11-6
Form Liquid
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: N-Butyl-N-(4-hydroxybutyl)nitrosamine, BBN supplier, Animal Modeling, inhibitors, activators


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