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N-Acetyl-L-glutamic acid

Cat. No. M20006
N-Acetyl-L-glutamic acid  Structure
Synonym:

N-Acetylglutamate

Size Price Availability Quantity
500mg USD 40  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

N-Acetyl-L-glutamic acid is an N-acyl-L-amino acid that is a component of animal cell culture media. It is the first intermediate involved in arginine biosynthesis in prokaryotes and simple eukaryotes, and is a regulator of the urea cycle.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 189.17
Formula C7H11NO5
CAS Number 1188-37-0
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C
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Keywords: N-Acetyl-L-glutamic acid , N-Acetylglutamate supplier, Endogenous Metabolite, inhibitors

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