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N-Acetyl-L-glutamic acid

Cat. No. M20006
N-Acetyl-L-glutamic acid  Structure
Synonym:

N-Acetylglutamate

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500mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

N-Acetyl-L-glutamic acid is an N-acyl-L-amino acid that is a component of animal cell culture media. It is the first intermediate involved in arginine biosynthesis in prokaryotes and simple eukaryotes, and is a regulator of the urea cycle.

Chemical Information
Molecular Weight 189.17
Formula C7H11NO5
CAS Number 1188-37-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bin Xia, et al. Environ Int. Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence

[2] Hirofumi Okabayashi, et al. Biopolymers. Fourier transform IR study of aggregational behavior of N-acetyl-L- and N-butyloxycarbonyl-L-glutamic acid oligomeric benzyl esters in dioxane and benzene: beta-turn --> antiparallel beta-sheet transition

[3] A J Dobson, et al. Acta Crystallogr C. N-acetyl-L-glutamic acid

[4] D S Hoare, et al. J Bacteriol. Deacetylation of N-acetyl-L-glutamic acid by Neurospora crassa

[5] J V Auditore, et al. J Neurochem. Occurrence of N-acetyl-L-glutamic acid in the human brain

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