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Myoseverin 

Cat. No. M29763

All AbMole products are for research use only, cannot be used for human consumption.

Myoseverin  Structure

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Quality Control & Documentation
Biological Activity

Myoseverina, a microtubule-binding molecule, induces the reversible fission of multinucleated myotubes into mononucleated fragments. Myoseverina affects the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with the activation of pathways involved in wound healing and tissue regeneration.

Chemical Information
Molecular Weight 432.52
Formula C24H28N6O2
CAS Number 267402-71-1
Form Solid
Solubility (25°C) DMSO 250 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Dominic C H Ng, et al. Cell Motil Cytoskeleton. Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition

[2] Hyo-Eun Park, et al. DNA Cell Biol. Myoseverin is a potential angiogenesis inhibitor by inhibiting endothelial cell function and endothelial progenitor cell differentiation

[3] Claudio Vismara, et al. Birth Defects Res B Dev Reprod Toxicol. Determination of myoseverin embryotoxic potential by using FETAX

[4] Y T Chang, et al. J Med Chem. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors

[5] G R Rosania, et al. Nat Biotechnol. Myoseverin, a microtubule-binding molecule with novel cellular effects

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Keywords: Myoseverin  supplier, Microtubule, inhibitors, activators

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