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MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis.
| Molecular Weight | 373.41 |
| Formula | C20H19N7O |
| CAS Number | 681282-09-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 2.4 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related c-Myc Products |
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MDEG-541 is a potent MYC-MAX degrader. |
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c-Myc inhibitor 11 is a c-MYC inhibitor (pEC50: 6.4). |
| c-Myc inhibitor 12
c-Myc inhibitor 12 is an inhibitor of c-Myc with a pEC50 of 6.4. |
| m-Se3
m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity. |
| c-Myc inhibitor 10
c-Myc inhibitor 10, a c-Myc inhibitor, exhibits increased cellular potency, consistent with an increase in permeability with methylation of the morpholine nitrogen. |
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