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Recombinant mouse IFN-γ (E. coli)

Cat. No. M9865
Recombinant mouse IFN-γ (E. coli) Structure
Synonym:

Murine IFN-γ

Size Price Availability Quantity
20ug USD 110  USD110 In stock
100ug USD 210  USD210 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant mouse IFN-γ (Murine IFN-γ)(E. coli) is an unstable interferon produced by CD4 and CD8 T lymphocytes and activated NK cells. IFN-γ receptors are present in most immune cells, and they respond to IFN-γ signaling by increasing the surface expression of class I γ proteins. Interferon-γ signals in antigen presentation, cell and antigen recognition B and T lymphocytes, and regulate the antigen-specific immune response period. In addition, interferon-γ stimulates many lymphocyte functions, including the antimicrobial and antitumor responses of macrophages, NK cells and neutrophils.

ED50 < 0.15 ng/ml, measured by cytotoxicity assay using WEHI-279 cells.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant mouse IFN-γ (E. coli), Murine IFN-γ supplier, Recombinant Proteins, inhibitors, activators


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