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MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions (IC50 = 10 nM). MSX-122 blocks invasion and angiogenesis in vitro. MSX-122 attenuates colonic damage in mice with experimental colitis. MSX-122 blocks metastasis in an experimental animal model of breast cancer metastasis.
| Molecular Weight | 292.34 |
| Formula | C16H16N6 |
| CAS Number | 897657-95-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Liang Z, et al. PLoS One. Development of a unique small molecule modulator of CXCR4.
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