All AbMole products are for research use only, cannot be used for human consumption.
MRTX849 (Adagrasib) is a potent, highly selective, oral available KRAS G12C inhibitor. MRTX849 (Adagrasib) maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. MRTX849 (Adagrasib) exhibited significantly improved half-life and penetration into the tumor, shutting down KRAS signaling for the entire dosing interval, and showing a higher degree of antitumor activity than previous KRAS mutant-selective inhibitors.
iScience. 2023 Jan 28;26(2):106080..
Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
MRTX849 (Adagrasib) purchased from AbMole
| Molecular Weight | 604.12 |
| Formula | C32H35ClFN7O2 |
| CAS Number | 2326521-71-3 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Ras Products |
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| AMG410
AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. |
| HRS-4642
HRS-4642 is a selective KRAS(G12D) inhibitor, with Kd value of 0.083 nM. HRS-4642 has anti-cancer activity. HRS-4642 exhibits significant in vivo potency. |
| AZD0022
AZD0022 is a selective and orally active KRASG12D inhibitor. |
| HH0043
HH0043 is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. |
| BI-2493
BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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