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MRT-10

Cat. No. M8241

All AbMole products are for research use only, cannot be used for human consumption.

MRT-10 Structure

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Biological Activity

MRT-10 is a novel, high-affinity antagonist of smoothened (Smo). MRT-10 displaces labeled cyclopamine from Smo with an IC50 of 500 nM, and inhibits shh-induced Gli-reporter activity in Shh-light2 cells (IC50 = 0.64 μM).

Chemical Information
Molecular Weight 465.52
Formula C24H23N3O5S
CAS Number 330829-30-6
Solubility (25°C) DMSO: ≥15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rosanna Marino, et al. Unraveling the Relationship between Milk Yield and Quality at the Test Day with Rumination Time Recorded by a PLF Technology

[2] Ali Kiani, et al. Digestive physiology of captive capybara (Hydrochoerus hydrochaeris)

[3] Antonio Solinas, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity

[4] Fabrizio Manetti, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists

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Keywords: MRT-10 supplier, inhibitors, activators

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