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MRT-10 is a novel, high-affinity antagonist of smoothened (Smo). MRT-10 displaces labeled cyclopamine from Smo with an IC50 of 500 nM, and inhibits shh-induced Gli-reporter activity in Shh-light2 cells (IC50 = 0.64 μM).
| Molecular Weight | 465.52 |
| Formula | C24H23N3O5S |
| CAS Number | 330829-30-6 |
| Solubility (25°C) | DMSO: ≥15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Ali Kiani, et al. Digestive physiology of captive capybara (Hydrochoerus hydrochaeris)
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