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MP7

Cat. No. M55320
MP7 Structure
Synonym:

MP-7; PDK1 inhibitor

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Quality Control & Documentation
Biological Activity

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.

Chemical Information
Molecular Weight 516.50
Formula C28H22F2N4O4
CAS Number 1001409-50-2
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related PDK1 Products
PDKtide

PDKtide is a biological active peptide.

PDK1-IN-RS2 

PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.

PS47 

PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48.

PS210

PS210 is a potent activator of PDK1 that binds to the PIF-pocket and allosterically modulates the active site of PDK1.

WAY-299338

WAY-299338 is a modulator of the Protein Kinase PDK1.

  Catalog
Abmole Inhibitor Catalog




Keywords: MP7, MP-7; PDK1 inhibitor supplier, PDK1, inhibitors, activators


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