About 22 results found for searched term "PDK1" (0.363 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21648 | PDK4-IN-1 hydrochloride | Apoptosis |
| PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. | ||
| M28769 | PDK1-IN-RS2 | PDK1 |
| PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. | ||
| M42534 | PDK-IN-1 | PDHK |
| PDK-IN-1 is a pyruvate dehydrogenase kinase (PDK) inhibitor. | ||
| M42593 | PKM2/PDK1-IN-1 | Pyruvate Kinase |
| PKM2/PDK1-IN-1, one of shikonin thioether derivatives, is a dual inhibitor of PKM2/PDK1. | ||
| M1848 | OSU-03012 | PDK1 |
| OSU03012 | ||
| OSU-03012 is a novel and potent inhibitor of PDK-1 with an IC50 of 5 µM. | ||
| M2115 | GSK2334470 | PDK1 |
| GSK2334470 is a highly specific and potent inhibitor of PDK1 with IC50 of 10 nM. | ||
| M2310 | BX-795 | PDK1 |
| BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively. | ||
| M2311 | BX-912 | PDK1 |
| BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. | ||
| M4361 | Polyphyllin-I | JNK |
| Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. | ||
| M4832 | NVP-BAG956 | PDK1 |
| BAG956 | ||
| NVP-BAG956 is a potent, ATP-competitive and selective dual PDK1 and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively). | ||
| M6857 | JX 06 | Others |
| JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor. | ||
| M7562 | BX517 | PDK1 |
| BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM. | ||
| M7989 | PS48 | Others |
| PS48 is a PDK1 (phosphoinositide-depende |
||
| M9360 | Dicoumarol | PDK1 |
| Dicumarol | ||
| Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively. | ||
| M20162 | WAY-352098 | PDK1 |
| WAY-352098 is a modulator of the Protein Kinase PDK1 | ||
| M20367 | WAY-298630 | PDK1 |
| WAY-298630 is a PDK1 modulator | ||
| M20385 | WAY-299338 | PDK1 |
| WAY-299338 is a modulator of the Protein Kinase PDK1. | ||
| M20816 | PS210 | PDK1 |
| PS210 is a potent activator of PDK1 that binds to the PIF-pocket and allosterically modulates the active site of PDK1. | ||
| M27891 | PS47 | PDK1 |
| PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48. | ||
| M28603 | PS10 | PDHK |
| PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase | ||
| M28806 | VER-246608 | PDHK |
| VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively. | ||
| M30106 | NU6102 | CDK |
| NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 μM), DYRK1A (IC50 of 0.9 μM), PDK1 (IC50 of 0.8 μM) and ROCKII (IC50 of 0.6 μM). | ||
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