Free shipping on all orders over $ 500

Recently Added

Sign In
Sign Up
Contact Us

AZD7545

Cat. No. M2423

All AbMole products are for research use only, cannot be used for human consumption.

AZD7545 Structure

Size	Price	Availability	Quantity
5mg	USD 140 USD140	In stock
10mg	USD 200 USD200	In stock
25mg	USD 360 USD360	In stock

Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation

Purity: >99.0%
COA
MSDS

Product Information

Biological Activity

AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively.

Chemical Information

Molecular Weight	478.87
Formula	C19H18ClF3N2O5S
CAS Number	252017-04-2
Form	Solid
Solubility (25°C)	DMSO 80 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Naoyuki Makita, et al. Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism

[2] Masato Kato, et al. Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

[3] Alina Tuganova, et al. Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2

[4] J A Morrell, et al. AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

[5] R M Mayers, et al. AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

Related PDK1 Products
MP7 MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 (PDK1) inhibitor.
PDKtide PDKtide is a biological active peptide.
PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
PS47 PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48.
PS210 PS210 is a potent activator of PDK1 that binds to the PIF-pocket and allosterically modulates the active site of PDK1.

Catalog

Abmole Inhibitor Catalog

Keywords: AZD7545 supplier, PDK1, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

Get to Know Us

Customer Support

Resources

Contact Us

Tel: +1-800-660-8580
Email: [email protected]

Tel: +32 (0)2 738 09 61
Email: [email protected]

Worldwide Distributors

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.