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Tesirine

Cat. No. M28641

All AbMole products are for research use only, cannot be used for human consumption.

Tesirine Structure
Synonym:

SG3249

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Quality Control & Documentation
Biological Activity

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity.

Chemical Information
Molecular Weight 1496.65
Formula C75H101N9O23
CAS Number 1595275-62-9
Form Solid
Solubility (25°C) DMSO 200 mg/mL (ultrasonic)
Storage -20°C, protect from light, sealed
References

[1] Bo Xu. Eur J Clin Pharmacol. Loncastuximab tesirine: an effective therapy for relapsed or refractory diffuse large B-cell lymphoma

[2] Arnold Lee. Drugs. Loncastuximab Tesirine: First Approval

[3] No authors listed. Am J Health Syst Pharm. Loncastuximab Tesirine-lpyl

[4] No authors listed. Loncastuximab Tesirine

[5] Paolo F Caimi, et al. Lancet Oncol. Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial

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  Catalog
Abmole Inhibitor Catalog




Keywords: Tesirine, SG3249 supplier, Drug-Linker Conjugates for ADC, inhibitors, activators

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