About 5 results found for searched term "Tesirine" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M24839 | Loncastuximab tesirine | Drug-Linker Conjugates for ADC |
| zz-lpyl; ADCT-402 | ||
| Loncastuximab tesirine is a human cluster of differentiation 19 (CD19)-directed antibody-drug conjugate (ADC). Once bound to CD19 on the cell membrane, loncastuximab tesirine is rapidly internalised and triggers cell death. Loncastuximab tesirin induces cell apoptosis, it can be used for the research of diffuse large B-cell lymphoma. | ||
| M28641 | Tesirine | Drug-Linker Conjugates for ADC |
| SG3249 | ||
| Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity. | ||
| M24736 | Rovalpituzumab | Notch |
| Rovalpituzumab is a humanized monoclonal antibody against delta-like protein 3 (DLL3). Rovalpituzumab can be used in the synthesis of antibody-drug conjugate (ADC), Rovalpituzumab Tesirine. Rovalpituzumab has activity against small cell lung cancer (SCLC). | ||
| M28642 | SG3199 | DNA Alkylator/Crosslinker |
| SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249). | ||
| M41008 | Val-Ala-PABC-Exatecan | Drug-Linker Conjugates for ADC |
| Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor). | ||
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