Moxonidine is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.
Molecular Weight | 241.68 |
Formula | C9H12ClN5O |
CAS Number | 75438-57-2 |
Form | Solid |
Solubility (25°C) | 24 mg/mL in DMSO |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Imidazoline Receptor Products |
---|
Harmane
Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). |
RX 801077
RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. |
Allantoin
Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth. |
Agmatine sulfate
Agmatine sulfate is a α 2 ligand. Also imidazoline ligand. |
Rilmenidine Phosphate
Rilmenidine Phosphate is a selective I imidazoline receptor agonist which is used for the treatment of hypertension. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.