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Morrhuate sodium

Cat. No. M25572
Morrhuate sodium Structure
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Biological Activity

Morrhuate sodium is the sodium salt of fatty acids in cod liver oil and can be used to construct rabbit osteomyelitis models.

Chemical Information
Molecular Weight 564.4
Formula C20H18N6Na2O9S
CAS Number 8031-09-2
Form Solid
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiaoli Li, et al. Int J Nanomedicine. Delivery of sodium morrhuate to hemangioma endothelial cells using immunoliposomes conjugated with anti-VEGFR2/KDR antibody

[2] David Rabago, et al. J Altern Complement Med. Dextrose and morrhuate sodium injections (prolotherapy) for knee osteoarthritis: a prospective open-label trial

[3] J-H Zhao, et al. Int J Oral Maxillofac Surg. Sclerotherapy of oral and facial venous malformations with use of pingyangmycin and/or sodium morrhuate

[4] D F Stroncek, et al. J Lab Clin Med. Sodium morrhuate stimulates granulocytes and damages erythrocytes and endothelial cells: probable mechanism of an adverse reaction during sclerotherapy

[5] J A Maynard, et al. J Orthop Res. Morphological and biochemical effects of sodium morrhuate on tendons

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