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Moracin O

Cat. No. M17335

All AbMole products are for research use only, cannot be used for human consumption.

Moracin O Structure
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5mg USD 450  USD450 In stock
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Biological Activity

Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects. Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM.

Chemical Information
Molecular Weight 326.34
Formula C19H18O5
CAS Number 123702-97-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Besse Hardianti, et al. Mol Med Rep. Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway

[2] Nak-Kyun Soung, et al. Exp Mol Med. Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

[3] Xiao-Ke Zheng, et al. Phytochemistry. Phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity in vitro

[4] Ju Hee Lee, et al. Eur J Pharmacol. Moracin M inhibits airway inflammation by interrupting the JNK/c-Jun and NF-κB pathways in vitro and in vivo

[5] Navneet Kaur, et al. Chem Commun (Camb). The first total synthesis of moracin O and moracin P, and establishment of the absolute configuration of moracin O

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Keywords: Moracin O supplier, ROS, inhibitors, activators

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