Free shipping on all orders over $ 500

ML352 

Cat. No. M28777

All AbMole products are for research use only, cannot be used for human consumption.

ML352  Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively.

Chemical Information
Molecular Weight 387.47
Formula C21H29N3O4
CAS Number 1649450-12-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jeanette L Bertron, et al. Bioorg Med Chem Lett. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound

[2] Sean R Bollinger, et al. Bioorg Med Chem Lett. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter

[3] Elizabeth A Ennis, et al. ACS Chem Neurosci. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter

Related AChR/AChE Products
AT 1001

AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM.

Dihydro-β-erythroidine hydrobromide

Dihydro-β-erythroidine hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively.

Spinosad

Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.

TAE-1 

TAE-1 is a potent inhibitor of AChE and BuChE.

PE154 

PE154 is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively).

  Catalog
Abmole Inhibitor Catalog




Keywords: ML352  supplier, AChR/AChE, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.