MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 80 mg/mL|
MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate
Douglas C Beshore, et al. ACS Med Chem Lett. 2018 Apr 30;9(7):652-656. PMID: 30034595.
Randomized, controlled, proof-of-concept trial of MK-7622 in Alzheimer's disease
Tiffini Voss, et al. Alzheimers Dement (N Y). 2018 Apr 26;4:173-181. PMID: 29955661.
Preclinical to Human Translational Pharmacology of the Novel M 1 Positive Allosteric Modulator MK-7622
Jason M Uslaner, et al. J Pharmacol Exp Ther. 2018 Jun;365(3):556-566. PMID: 29563325.
|Related AChR/AChE Products|
|Scopolamine hydrobromide trihydrate
Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM.
Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue.
Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb.
Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.
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