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MK-7622

Cat. No. M9768
MK-7622 Structure
Size Price Availability Quantity
10mg USD 135  USD150 In stock
25mg USD 270  USD300 In stock
50mg USD 405  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 399.48
Formula C25H25N3O2
CAS Number 1227923-29-6
Purity >98.5%
Solubility DMSO ≥ 80 mg/mL
Storage at -20°C
References

MK-7622: A First-in-Class M 1 Positive Allosteric Modulator Development Candidate
Douglas C Beshore, et al. ACS Med Chem Lett. 2018 Apr 30;9(7):652-656. PMID: 30034595.

Randomized, controlled, proof-of-concept trial of MK-7622 in Alzheimer's disease
Tiffini Voss, et al. Alzheimers Dement (N Y). 2018 Apr 26;4:173-181. PMID: 29955661.

Preclinical to Human Translational Pharmacology of the Novel M 1 Positive Allosteric Modulator MK-7622
Jason M Uslaner, et al. J Pharmacol Exp Ther. 2018 Jun;365(3):556-566. PMID: 29563325.

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  Catalog
Abmole Inhibitor Catalog 2017




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