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MK 0893

Cat. No. M13971
MK 0893 Structure
Size Price Availability Quantity
5mg USD 393  USD393 In stock
10mg USD 662  USD662 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 588.48
Formula
CAS Number 870823-12-4
Purity >99%
Solubility DMSO ≥ 33.33 mg/mL
Storage at -20°C
References

[1] Fengbin Song, et al. Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists

[2] Ali Jazayeri, et al. Extra-helical binding site of a glucagon receptor antagonist

[3] Hong-Ping Guan, et al. Glucagon receptor antagonism induces increased cholesterol absorption

[4] Songnian Lin, et al. A novel series of indazole-/indole-based glucagon receptor antagonists

[5] Yusheng Xiong, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes

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