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MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist (Ki =1.6 nM). MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice.
| Molecular Weight | 406.41 |
| Formula | C22H18FN4O3 |
| CAS Number | 328232-95-7 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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