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(-)-DHMEQ

Cat. No. M11454
(-)-DHMEQ Structure
Synonym:

Dehydroxymethylepoxyquinomicin

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

(-) - DHMEQ (Dehydroxymethylepoxyquinomicin) is an effective and selective and irreversible nf-kappa B inhibitors, covalent binding and cysteine residues. (-)-DHMEQ inhibited nuclear NF-κB translocation and showed anti-inflammatory and anticancer activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 261.23
Formula C13H11NO5
CAS Number 287194-40-5
Purity >98%
Solubility DMSO ≥ 40 mg/mL
Storage -20°C , dry , sealed
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Keywords: (-)-DHMEQ, Dehydroxymethylepoxyquinomicin supplier, NF-κB, inhibitors

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