Free shipping on all orders over $ 500

Mazdutide acetate

Cat. No. M25470
Mazdutide acetate Structure
Synonym:

IBI362 acetate; LY3305677 acetate

Size Price Availability Quantity
1mg USD 105  USD105 In stock
5mg USD 320  USD320 In stock
10mg USD 540  USD540 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Mazdutide (IBI362, LY3305677) is a novel glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Mazdutide (IBI362, LY3305677) was well tolerated. It can be used in studies of obesity and type 2 diabetes (T2D).

Chemical Information
CAS Number 2259884-03-0 (free base)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Linong Ji, et al. EClinicalMedicine. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial

[2] Linong Ji, et al. EClinicalMedicine. Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial

[3] Hongwei Jiang, et al. Nat Commun. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

[4] Hongwei Jiang, et al. Nat Commun. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

Related Glucagon Receptor Products
Glucagon (19-29), human

Glucagon (19-29), human is a potent and efficient inhibitor of insulin secretion.

Exendin-3/4 (59-86)

Exendin-3/4 (59-86) is a Exendin-4 peptide derivative.

HAEGTFTSDVS

HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

GLP-1(32-36)amide

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1.

HAEGTFTSD

HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide.

  Catalog
Abmole Inhibitor Catalog




Keywords: Mazdutide acetate, IBI362 acetate; LY3305677 acetate supplier, Glucagon Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.