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MAP4343 

Cat. No. M30216

All AbMole products are for research use only, cannot be used for human consumption.

MAP4343  Structure

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Quality Control & Documentation
Biological Activity

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.

Chemical Information
Molecular Weight 330.5
Formula C22H34O2
CAS Number 511-26-2
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Giovana C Macedo, et al. Neuropsychopharmacology. Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder

[2] Nicolas Froger. Biol Aujourdhui. [New therapeutic avenues for neurosteroids in psychiatric diseases]

[3] Etienne-Emile Baulieu. Front Endocrinol (Lausanne). Steroids and Brain, a Rising Bio-Medical Domain: a Perspective

[4] Lucie Parésys, et al. Int J Neuropsychopharmacol. Effects of the Synthetic Neurosteroid: 3β-Methoxypregnenolone (MAP4343) on Behavioral and Physiological Alterations Provoked by Chronic Psychosocial Stress in Tree Shrews

[5] Massimiliano Bianchi, et al. Proc Natl Acad Sci U S A. 3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders

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Keywords: MAP4343  supplier, Microtubule, inhibitors, activators

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